10-20mg orally is a good starting dose. You shouldn't have to do a cold water extraction at this dosage. Taking more could result in nausea and puking. Also, if you don't want to waste a bunch of hydro, try to consume when your stomach is empty.
Hydrocodone pills come in 5mg, 7.5mg and 10mg doses. There are currently no hydrocodone-only preparations in the US, although a new formulation known as Zohydro is supposed to come out in the first half of 2013 which will be a hydrocodone-only extended release pill. Generally, hydrocodone will have acetaminophen (in the case of Vicodin and its generic counterparts), although it may have ibuprofen (Vicoprofen) or aspirin (Lortab ASA). The acetaminophen/ibuprofen/aspirin will be the second number on the pill bottle (for example a 10/500 pill is 10mg Hydrocodone and 500mg acetaminophen). Hydrocodone recreational dose chart for opiate naive users:
|Tolerance||First time||Low tolerance||Medium tolerance||High tolerance|
There is some debate, even in the scientific community, as to whether hydrocodone is a prodrug or has some activity of its own. Hydrocodone is metabolized by the CYP2D6 enzyme into hydromorphone, which has a lot of activity. Some believe this to indicate that most of hydrocodone's effect is actually from hydromorphone.
However, studies have been done with people whose CYP2D6 enzymes don't work properly, and they have been found to feel some effect from hydrocodone, implying it has at least some activity. There's a good discussion on Opiophile about this.
Another study (linked in references) was found with people who's CYP2D6 enzymes worked properly. They were dosed once, then at a later time, had their enzyme inhibited using quinidine, and were dosed again. No difference in effect was noted, showing that Hydromorphone has essentially no effect on the action of Hydrocodone.
Eating is generally the easiest method of consuming it. Threads about snorting hydrocodone are a source of a great deal of rage on 420chan's /opi/ due to the APAP in the pill. Shooting it is also not recommended, due to a possible histamine reaction, though it is far less dangerous to do than with Codeine, and there have been several reports of people doing it. The efficacy of hydrocodone can be increased by at least 10% by taking them rectally.
All of the following have been known to potentiate hydrocodone.
- Grapefruit juice
- Doxylamine Succinate
The following potentiate hydrocodone but are dangerous to mix together. Too high of a dose can cause respiratory depression and death. Watch your doses if you're adding in any of these chemicals.
The orally effective narcotics have much in common with alcohol as far as absorption goes, and the following methods have been demonstrated to have at least some effectiveness in getting the drug into the system more quickly:
- Mixing cough syrup or solutions of drug with carbonated beverages
- Mixing cough syrup or solutions of drug with Gatorade
- Mixing cough syrup or solutions of drug with warm brandy
- Using one form or another of the opiate to fortify an over-the-counter cough syrup
- Preparing a sodium bicarbonate (baking soda) solution or capsule containing the drug
- Dissolving/mixing the drug in soup or chocolate pudding
- Mixing Hydrocodone cough syrup or liquid into tonic water
Opiates in general tend to have a very long shelf life; morphine in vials has been found to still be potent after 100 years. One Taimapedia contributor has used hydrocodone/APAP tablets that expired in 1999 and found them to have lost little to no strength.
"500mg" and "750mg Vicodin"
In case you missed it before, despite what many underage users on /opi/ may believe, hydrocodone pills do not come in 500mg and 750mg versions. They are in 5, 7.5 and 10mg pills, and anyone who tells you they are selling a 500mg Vicodin is lying to you, or generally retarded. This misconception comes from the measure of the dose of acetaminophen in the pill. Oh and also, too much Acetaminophen will cause liver failure, which is Deadly