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Opiate Tolerance

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A few thoughts on the build up of tolerance and the resulting increase in physical dependency

(I will flesh this out in a more orderly fashion at a later date, or maybe someone can organize it for me) -- I've had a go at cleaning it up a little and will have another go at it when more pods arrive. -Baron

There has been some misinformation floating around here about how the different classes of opiates (morphine/codiene, hydro codone/morph, oxy codone/morph ect.) produce different tolerances and addictions, and you can prevent overall opioid tolerance/physical dependence from building by rotating from one "class" of opiates to the next.

This is glaringly false (and could potentially lead to the development of a serious dependency in someone who believes that by "rotating" opiates they are preventing addiction).

All common opioids produce cross tolerance with one another and physical dependency builds based on total opiate consumption, the spacing between your doses, the size of your dose, how long you have been using regularly, the binding affinity of the opioid being used, and ROA. Your body removes (downregulates) opioid receptors and decreases its natural production of endogenous opioids (endorphins, enkephalins) to compensate for the exogenous opioids flooding your brain. W/D's manifest when you abruptly stop feeding your dome-piece with pills or dope, and your body has barely any receptors and has slowed its in-house opiate production to a trickle. It doesn't matter what opiate you are taking, they all do this. Some just bind to more receptors at a lower dose while prolonged use and high doses force your body to create less areas for the opioid to bind to. Swiching from say morphine to oxycodone is not going to prevent this compensation from happening. And again, switching from a strong opiate (ie heroin to HC) to a weaker one of a different class is not going to prevent the build up of tolerance or withdrawal either, you are just going to have to take a larger, equipotent dose of the weaker opiate to achieve the same level of buzz you get from the stronger one.


Unfortunately, once you have established any kind of serious opiate tolerance it never really fully dissipates back to the "opiate-naive" level. Also, opiate tolerance is notorious for rapidly soaring back to and above pre-break levels, once you resume use, much faster than it took to originally develop (days versus weeks/months/years). If you are just starting out, heed these warning. If you can force yourself to take a serious tolerance break, restart your use with a DXM pre-game and better dosing habits. If you refuse to/are physically unable to do either of those then maybe conduct some cutting edge experimentation on the effect of using an ultra-low dose of an opiate antagonist (ie naltrexone) to greatly decrease, if not totally eliminate tolerance on a dose-by-dose basis. There has actually been some serious research into pairing a minuscule dose of antagonist with a full-blown agonist for the creation of pain pills that address the lack of ceiling for opioid tolerance and the ever-increasing severity of physical dependency, arguably the two most worrisome drawbacks of a therapeutic opioid regimen.

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